Integrated PlatformInnovative Solutions
A major challenge in conventional drug discovery and development is having to sort through the large number of hits derived through conventional screening.
Pyramid: Fragment-Based Drug Discovery
Pyramid defines a process by which a range of high-throughput biophysical and computational techniques are used to experimentally characterize the interactions of very low molecular weight compounds (fragments) with their target proteins.
- Designed to reduce attrition during drug development
- Carefully monitors key characteristics such as ligand efficiency and in vivo activity during lead optimization
- Ensures delivery of potent, selective and low molecular weight compounds with optimized drug metabolism and pharmacokinetic properties
- Generates higher quality leads by optimizing key drug properties earlier in the process
Pyramid has been successfully applied by Astex Pharmaceuticals across a wide variety of therapeutic targets and disease areas, including those regarded as “intractable” by the pharmaceutical industry.