- Clinical Pipeline
- Guadecitabine (SGI-110) DNMT inhibitor (Hematological Malignancies and Solid Tumors)
- ASTX029 Extracellular Signal-Related Protein Kinases (ERK 1/2) Inhibitor (Solid Tumors)
- Oral Decitabine and Cedazuridine (ASTX727) (Hematological Malignancies)
- ASTX660 Dual IAP Antagonist (Solid Tumors & Lymphomas)
- ASTX295 Oral Murine Double Minute 2 (MDM2) antagonist (Solid Tumors)
- Partnered Products and Programs
- Kisqali®(ribociclib) CDK4/6 inhibitor (Oncology)
- Balversa® (erdafitinib) FGFr inhibitor (Oncology)
- AZD5363 PKB/Akt Inhibitor (Oncology)
- Multiple Targets and Therapeutic Areas
- Pyramid™ Discovery Platform
- Oncology and CNS Discovery
- Sustaining Innovation
Phase 1 | Phase 2 | Phase 3 |
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TAS1553
Oral small molecule ribonucleotide reductase (RNR) inhibitor (Hematological Malignancies)
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Ownership: Taiho
Mechanism of Action: Ribonucleotide reductase (RNR) inhibitor
Indications: Relapsed or refractory (r/r) Acute Myeloid Leukemia (AML) and other myeloid neoplasms
How this therapy can help
TAS1553, a novel small molecule ribonucleotide reductase (RNR) inhibitor, for the treatment of r/r AML and other myeloid neoplasms (high risk myeloproliferative neoplasms (MPN), including accelerated phase, and myelodysplastic syndromes (MDS)/MPNs) where approved therapies have failed or for whom known life-prolonging therapies are not available. TAS1553 is a potent inhibitor of RNR. Ribonucleotide reductase is a key enzyme that mediates the synthesis of deoxyribonucleotides (dNTPs). Ribonucleotide reductase catalyzes the reduction of ribonucleotides into dNTPs, the substrates for DNA replication. Because RNR is the gatekeeper of dNTP homeostasis, the enzyme has long been recognized as a cancer therapeutic target, due to its necessity for cell replication.
Clinical status
TAS1553 is being evaluated in a first-in-human Phase 1 clinical study in patients with r/r AML and other myeloid neoplasms.