Harvey Ras (H-Ras) is a membrane-associated GTPase with critical functions in cell proliferation and differentiation. The G12V mutant of H-Ras is one of the most commonly encountered oncoproteins in human cancer. This mutation disrupts the GTPase activity of H-Ras, leading to constitutive activation and aberrant downstream signalling. Here we report the backbone resonance assignments of human H-Ras mutant G12V lacking the C-terminal membrane attachment domain.
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Amin et al.. “1H, 15N and 13C backbone assignments of GDP-bound human H-Ras mutant G12V.” Springer Link. 15 September 2015. DOI: 10.1007/s12104-015-9649-4