del Pozo et al: “Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity”, J. Med Chem. 2026

del Pozo et al: “Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity”, J. Med Chem. 2026

https://doi.org/10.1021/acs.jmedchem.6c01318

 

 

Gao et al: “Altered Inflammatory Signature in a C9ORF72 -ALS iPSC-Derived Motor Neuron and Microglia Coculture Model”, Glia. 2026

Gao et al: “Altered Inflammatory Signature in a C9ORF72 -ALS iPSC-Derived Motor Neuron and Microglia Coculture Model”, Glia. 2026

https://doi.org/10.1002/glia.70084

 

 

Sheth et al: “Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays”, Clin Chem Lab Med. 2026

Sheth et al: “Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays”, Clin Chem Lab Med. 2025/2026

https://doi.org/10.1515/cclm-2025-0610

 

 

Callahan, et al: “The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of COPD”, J Med Chem. 2026

Callahan, et al: “The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of COPD”, J. Med Chem. 2026

https://pubs.acs.org/jmcmar/article/69/17/20859/5256079/The-Discovery-of-GSK3227634-A-Potent-Inhaled

 

 

Ma et al: “From KRASG12D to Pan-KRAS Inhibitors ─ A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design”, J. Med Chem. 2026

Ma et al: “From KRASG12D to Pan-KRAS Inhibitors ─ A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design”, J. Med Chem. 2026

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c03662

 

 

Twigg et al: “Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective” J. Med Chem. 2025

Twigg et al: “Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective” J. Med Chem. 2025

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02894

 

 

Downes et al: “Design, modular synthesis and screening of 58 shape-diverse 3-D fragments”, Chemica Science, 2025

Downes et al: “Design, modular synthesis and screening of 58 shape-diverse 3-D fragments”, Chemica Science, 2025

https://doi.org/10.1039/D5SC05819H

 

 

Poole et al; “Accelerating fragment-based drug discovery using grand canonical nonequilibrium candidate Monte Carlo”, Nature Commun., 2025

Poole et al; “Accelerating fragment-based drug discovery using grand canonical nonequilibrium candidate Monte Carlo”, Nature Commun., 2025

https://doi.org/10.1038/s41467-025-60561-3

 

 

Oruç et al: “Mapping the space of protein binding sites with sequence-based protein language models”, Bioinformatics, 2025

Oruç et al: “Mapping the space of protein binding sites with sequence-based protein language models”, Bioinformatics, 2025

https://doi.org/10.1093/bioinformatics/btaf284

 

 

Reeks and Mahajan, et al; “High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1”; Structure, 2025

Reeks and Mahajan, et al; “High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1”; Structure, 2025

https://doi.org/10.1016/j.str.2025.05.014