/wp-content/uploads/2019/11/logo_white.png 0 0 webadmin /wp-content/uploads/2019/11/logo_white.png webadmin2016-09-24 12:15:152016-11-30 09:41:41Fragment Based Drug Discovery: An Organic Synthesis Perspective
- Fragment hits bind with high energy interactions, so have high ligand efficiency (LE).
- Small libraries of fragments can sample chemical space more widely There are estimated to be ~ 1050 compounds < 500 MW, cf.
~106 fragments < 250 MW.
- Potencies in mM rather than μM range require sensitive biophysical techniques to detect interactions, e.g. X-Ray, NMR, SPR, ITC.
- Millimolar fragments can be converted to nanomolar leads with the support of structure based drug design.
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