Tiu et al; “IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial”; Nature Communications, 2026

Tiu et al; “IAP antagonist tolinapant (ASTX660) in combination with pembrolizumab in advanced solid tumors: a phase I trial”; Nature Communications, 2026

https://www.nature.com/articles/s41467-026-77552-7

 

 

del Pozo et al: “Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity”, J. Med Chem. 2026

del Pozo et al: “Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity”, J. Med Chem. 2026

https://doi.org/10.1021/acs.jmedchem.6c01318

 

 

Gao et al: “Altered Inflammatory Signature in a C9ORF72 -ALS iPSC-Derived Motor Neuron and Microglia Coculture Model”, Glia. 2026

Gao et al: “Altered Inflammatory Signature in a C9ORF72 -ALS iPSC-Derived Motor Neuron and Microglia Coculture Model”, Glia. 2026

https://doi.org/10.1002/glia.70084

 

 

Sheth et al: “Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays”, Clin Chem Lab Med. 2026

Sheth et al: “Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays”, Clin Chem Lab Med. 2025/2026

https://doi.org/10.1515/cclm-2025-0610

 

 

Callahan, et al: “The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of COPD”, J Med Chem. 2026

Callahan, et al: “The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of COPD”, J. Med Chem. 2026

https://pubs.acs.org/jmcmar/article/69/17/20859/5256079/The-Discovery-of-GSK3227634-A-Potent-Inhaled

 

 

2026 AACR (poster): Enabling fragment-based drug discovery for direct small molecule inhibition of MYC

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2026 AACR (poster): Enabling fragment-based drug discovery for direct small molecule inhibition of MYC

 

 

Ma et al: “From KRASG12D to Pan-KRAS Inhibitors ─ A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design”, J. Med Chem. 2026

Ma et al: “From KRASG12D to Pan-KRAS Inhibitors ─ A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design”, J. Med Chem. 2026

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c03662

 

 

AD/PD 2026 (poster): Drug Discovery Application of Complex Human iPSC-Derived Models of Neurodegeneration and Neuroinflammation

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AD/PD 2026 (poster): Drug Discovery Application of Complex Human iPSC-Derived Models of Neurodegeneration and Neuroinflammation

Twigg et al: “Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective” J. Med Chem. 2025

Twigg et al: “Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective” J. Med Chem. 2025

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c02894

 

 

SfN 2025 (poster): Probing the phosphorylation state of ABL1 (c-Abl) kinase and one of its targets, SNCA (alpha-synuclein), using ABL1 inhibitors

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SfN 2025 (poster): Probing the phosphorylation state of ABL1 (c-Abl) kinase and one of its targets, SNCA (alpha-synuclein), using ABL1 inhibitors