Clinical Pipeline

Phase 1Phase 2Phase 3

ASTX295

A synthetic small molecule that acts as an antagonist of Murine Double Minute 2 (MDM2)

.

Ownership: Astex

Mechanism of Action: ASTX295 is a synthetic small molecule that acts as an antagonist of human Murine Double Minute 2 (MDM2; human homolog also known as HDM2). MDM2 is an E3 ubiquitin ligase which tightly regulates the level and activity of the p53 tumor suppressor. ASTX295 is designed to block the interaction of MDM2 with p53 and to restore p53 function.

Indication: Advanced Solid Tumors

How this therapy can help

ASTX295 is an investigational agent designed to target and bind to MDM2 and to block its interaction with p53. ASTX295 has the potential to activate p53 and its tumor-suppressor functions and induce antitumor responses in cancers with a wild-type p53 gene.

Clinical status

ASTX295 is currently being evaluated in a Phase 1/2 study in patients with advanced solid tumors characterized by wild-type p53 to determine safety, pharmacokinetics and preliminary activity.

View clinical studies and status

View Presentations and Publications