Poole et al; “Accelerating fragment-based drug discovery using grand canonical nonequilibrium candidate Monte Carlo”, Nature Commun., 2025
https://doi.org/10.1038/s41467-025-60561-3
Oruç et al: “Mapping the space of protein binding sites with sequence-based protein language models”, Bioinformatics, 2025
https://doi.org/10.1093/bioinformatics/btaf284
Reeks and Mahajan, et al; “High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1”; Structure, 2025
https://doi.org/10.1016/j.str.2025.05.014
Zhang et al; “The identification of functional regions of MEK1 using CRISPR tiling screens”; Commun Biol , 2025
Sharp et al; “Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function”; Nat Commun., 2025
Churcher et al; “Return to Flatland“; Nat Rev Chem., 2025
Holvey et al; “Fragment-to-Lead Medicinal Chemistry Publications in 2023”; J. Med. Chem., 2025
© Astex Pharmaceuticals
All rights reserved
