Sustaining Innovation Postdocs and Projects

Dr Anu Priyanka

Molecular Sciences, Astex Pharmaceuticals and Department of Biochemistry, NKI (Netherlands Cancer Institute), Amsterdam

Deubiquitinating enzymes (DUBs) are associated with numerous cellular signalling pathways and are implicated in the pathology of diseases such as cancer and neurological disorders. Current DUB-targeted inhibitors have limited potencies and specificities. In this project, I used a combination of biophysical, biochemical and structure-based drug discovery approaches to investigate the mechanism of action of competitive and allosteric DUB inhibitors.

Recent publications:

Priyanka et al., “Mitoxantrone stacking does not define the active or inactive state of USP15 catalytic domain”; J. Struct. Biol. 2022