The 3’-untranslated regions (3’-UTRs) of genes play an important role in post-transcriptional regulation of gene expression, localization, stability and translation. Regulatory motifs in the 3’-UTRs could influence the stability and translation of their corresponding messenger RNAs, and perturbations in these regulatory mechanisms can lead to disease. In my project I will use RNA-seq gene expression data and machine learning approaches to refine the existing landscape of 3’-UTRs in the human genome and to identify novel 3’-UTR elements. Furthermore, I will investigate regulatory mechanisms associated with the novel 3’-UTRs and determine how these mechanisms impact neurodegenerative disorders. This will provide a framework for identifying potential novel targets and provide insights into disease pathways.