Sustaining Innovation Alumni

Dr Siddharth Sethi

Bioinformatics, Astex Pharmaceuticals and University College London

The 3’-untranslated regions (3’-UTRs) of genes play an important role in post-transcriptional regulation of gene expression, localization, stability and translation. Regulatory motifs in the 3’-UTRs could influence the stability and translation of their corresponding messenger RNAs, and perturbations in these regulatory mechanisms can lead to disease. During this project, I used RNA-seq gene expression data and machine learning approaches to refine the existing landscape of 3’-UTRs in the human genome and to identify novel 3’-UTR elements. My work identified potential regulatory mechanisms associated with novel 3’-UTRs in disease, and has provided a framework for identifying potential novel therapeutic targets.

Siddharth Sethi is now a Research Associate in the Bioinformatics team at Astex Pharmaceuticals, UK.

Recent publications:

Sethi et al., Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes. Nature Communications 2022;