Sustaining Innovation Postdocs and Projects

Dr Harry Jubb

CCI-Structural Bioinformatics, Astex Pharmaceuticals and the Wellcome Trust Sanger Institute

In collaboration with COSMIC at the Wellcome Trust Sanger Institute, I annotated cancer mutation data and created visualization interfaces that mapped these mutations onto 3D protein structures. This project increased our understanding of the cancer mutations that drive cancer progression, and suggested which mutations are likely to drive cell growth and proliferation. Furthermore, 3D modelling of cancer-associated mutations can highlight how amino acid changes impact the binding of existing drugs, and offers the potential of high-resolution mutation-guided drug discovery.

Recent publications:

Jubb, HC, Saini, HK, Verdonk, ML, Forbes, SA. COSMIC-3D provides structural perspectives on cancer genetics for drug discovery. Nature Genetics. 2018; DOI 10.1038/s41588-018-0214-9

Jubb HC, Higueruelo AP, Ochoa-montaño B, Pitt WR, Ascher DB, Blundell TL. Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures. J Mol Biol. 2017; DOI 10.1016/j.jmb.2016.12.004

Jubb HC, Pandurangan AP, Turner MA, Ochoa-montaño B, Blundell TL, Ascher DB. Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health. Prog Biophys Mol Biol. 2016; DOI 10.1016/j.pbiomolbio.2016.10.002

Forbes SA, Beare D, Boutselakis H, et al. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Res. 2017; DOI 10.1093/Fnar/Fgkw1121

Forbes SA, Beare D, Bindal N, et al. COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer. Curr Protoc Hum Genet. 2016; DOI 10.1002/cphg.21.