Sustaining Innovation Postdocs and Projects

Dr Harry Jubb

CCI-Structural Bioinformatics, Astex Pharmaceuticals and the Wellcome Trust Sanger Institute

In collaboration with COSMIC at the Wellcome Trust Sanger Institute, I annotated cancer mutation data and created visualization interfaces that mapped these mutations onto 3D protein structures. This project increased our understanding of the cancer mutations that drive cancer progression, and suggested which mutations are likely to drive cell growth and proliferation. Furthermore, 3D modelling of cancer-associated mutations can highlight how amino acid changes impact the binding of existing drugs, and offers the potential of high-resolution mutation-guided drug discovery.

Recent publications:

Tate JG, Bamford S, Jubb HC, et al. COSMIC: the Catologue of Somatic Mutations in Cancer. Nucleic Acids Res. 2019 DOI 10.1093/nar/gky1015

Jubb, HC, Saini, HK, Verdonk, ML, Forbes, SA. COSMIC-3D provides structural perspectives on cancer genetics for drug discovery. Nature Genetics. 2018; DOI 10.1038/s41588-018-0214-9